Publications

Selected publications

• V. Sairanen, A. Leemans, C.M.W. Tax, "Fast and accurate Slicewise OutLIer Detection (SOLID) with informed model estimation for diffusion MRI data", NeuroImage, Vol. 181, p. 331-346, 2018 - PubMed


• R. Heinen, N. Vlegels, J. de Bresser, A. Leemans, G.J. Biessels, Y.D. Reijmer; Utrecht Vascular Cognitive Impairment study group, "The cumulative effect of small vessel disease lesions is reflected in structural brain networks of memory clinic patients", Neuroimage Clin, Vol. 19, p. 963-969, 2018 - PubMed


• F. Arrigoni, A. De Luca, D. Velardo, F. Magri, S. Gandossini, A. Russo, M. Froeling, A. Bertoldo, A. Leemans, N. Bresolin, G. D'angelo, "Multiparametric quantitative MRI assessment of thigh muscles in limb-girdle muscular dystrophy 2A and 2B", Muscle Nerve, Vol. 58(4), p. 550-558, 2018 - PubMed


• A. Sierk, J.K. Daniels, A. Manthey, J.G. Kok, A. Leemans, M. Gaebler, J.P. Lamke, J. Kruschwitz, H. Walter, "White matter network alterations in patients with depersonalization/derealization disorder", J Psychiatry Neurosci, Vol. 43(5), p. 347-357, 2018 - PubMed


• Y.D. Reijmer, M.S. van den Heerik, R. Heinen, A. Leemans, J. Hendrikse, J.B. de Vis, L.A. van der Kleij, C. Lucci, M.E. Hendriks, M.J.E. van Zandvoort, I.M.C. Huenges Wajer, J.M.A. Visser-Meily, G.J.E. Rinkel, G.J. Biessels, M.D.I. Vergouwen, "Microstructural White Matter Abnormalities and Cognitive Impairment After Aneurysmal Subarachnoid Hemorrhage", Stroke, Vol. 49(9), p. 2040-2045, 2018 - PubMed


• T. Billiet, L. Emsell, M. Vandenbulcke, R. Peeters, D. Christiaens, A. Leemans, W. Van Hecke, A. Smeets, F. Amant, S. Sunaert, S. Deprez, "Recovery from chemotherapy-induced white matter changes in young breast cancer survivors?", Brain Imaging and Behavior, Vol. 12(1), p. 64-77, 2018 - PubMed


• J. Fitzgerald, A. Leemans, E. Kehoe, E. O'Hanlon, L. Gallagher, J. McGrath, "Abnormal fronto-parietal white matter organisation in the superior longitudinal fasciculus branches in autism spectrum disorders", European Journal of Neuroscience, Vol. 47(6), p. 652-661, 2018 - PubMed


• S. van Baalen, A. Leemans, P. Dik, M.R. Lilien, B. ten Haken, M. Froeling, "IVIM modeling in the kidneys: comparison of mono-, bi- and triexponential fit", Journal of Magnetic Resonance Imaging, Vol. 46(1), p. 228-239, 2017 - PubMed


• S.B. Vos, C.M.W. Tax, P.R. Luijten, S. Ourselin, A. Leemans, M. Froeling, "The importance of correcting for signal drift in diffusion MRI", Magnetic Resonance in Medicine, Vol. 77(1), p. 285-299, 2017 - PubMed


• L. Schlaffke, A. Leemans, L.M. Schweizer, S. Ocklenburg, T. Schmidt-Wilcke, "Learning Morse code alters microstructural properties in the inferior longitudinal fasciculus: A DTI study", Frontiers in Human Neuroscience, Vol. 11(383), p. 1-9, 2017 - PubMed


• M. Froeling, C.M.W. Tax, S.B. Vos, P.R. Luijten, A. Leemans, "The 'MASSIVE' brain dataset: Multiple Acquisitions for Standardization of Structural Imaging Validation and Evaluation", Magnetic Resonance in Medicine, Vol. 77(5), p. 1797-1809, 2017 - PubMed


• K. Keunen, M.J. Benders, A. Leemans, P.C. Fieret-Van Stam, L.H. Scholtens, M.A. Viergever, R.S. Kahn, F. Groenendaal, L.S. de Vries, M.P. van den Heuvel, "White matter maturation in the neonatal brain is predictive of school age cognitive capacities in children born very preterm", Dev Med Child Neurol, Vol. 59(9), p. 939-946, 2017 - PubMed


• S. O'Donoghue, L. Kilmartin, D. O'Hora, L. Emsell, C. Langan, S. McInerney, N.J. Forde, A. Leemans, B. Jeurissen, G.J. Barker, P. McCarthy, D.M. Cannon, C. McDonald, "Anatomical integration and rich-club connectivity in euthymic bipolar disorder", Psychological Medicine, Vol. 47(9), p. 1609-1623, 2017 - PubMed


• C.M.W. Tax, C.F. Westin, T. Dela Haije, A. Fuster, M.A. Viergever, E. Calabrese, L. Florack, A. Leemans, "Quantifying the brain's sheet structure with normalized convolution", Medical Image Analysis, Vol. 39, p. 162-177, 2017 - PubMed


• K.L. Ruddy, A. Leemans, D.G. Woolley, N. Wenderoth, R.G. Carson, "Structural and Functional Cortical Connectivity Mediating Cross Education of Motor Function", The Journal of Neuroscience, Vol. 37(10), p. 2555-2564, 2017 - PubMed


• K.L. Ruddy, A. Leemans, R.G. Carson, "Transcallosal connectivity of the human cortical motor network", Brain Structure and Function, Vol. 222(3), p. 1243-1252, 2017 - PubMed


• W. Haakma, B.A. Jongbloed, M. Froeling, S.H. Goedee, C. Bos, A. Leemans, L.H. van den Berg, J. Hendrikse, W.L. van der Pol, "MRI shows thickening and altered diffusion in the median and ulnar nerves in multifocal motor neuropathy", European Radiology, Vol. 27(5), p. 2216-2224, 2017 - PubMed


• H.J. van der Horn, J.G. Kok, M.E. de Koning, M.E. Scheenen, A. Leemans, J.M. Spikman, J. van der Naalt, "Altered wiring of the human structural connectome in adults with mild traumatic brain injury", Journal of Neurotrauma, Vol. 34(5), p. 1035-1044, 2016 - PubMed


• C.M.W. Tax, T. Dela Haije, A. Fuster, C.-F. Westin, M.A. Viergever, L. Florack, A. Leemans, "Sheet Probability Index (SPI): Characterizing the geometrical organization of the white matter with diffusion MRI", NeuroImage, Vol. 142, p. 260-279, 2016 - PubMed


• L. Serbruyns, I. Leunissen, P. van Ruitenbeek, L. Pauwels, K. Caeyenberghs, E. Solesio-Jofre, M. Geurts, K. Cuypers, R.L. Meesen, S. Sunaert, A. Leemans, S.P. Swinnen, "Alterations in brain white matter contributing to age-related slowing of task switching performance: The role of radial diffusivity and magnetization transfer ratio", Human Brain Mapping, Vol. 37(11), p. 4084-4098, 2016 - PubMed


• Y.D. Reijmer, P. Fotiadis, G. Piantoni, G. Boulouis, K.E. Kelly, M.E. Gurol, A. Leemans, M.J. O'Sullivan, S.M. Greenberg, A. Viswanathan, "Small vessel disease and cognitive impairment: The relevance of central network connections", Human Brain Mapping, Vol. 37(7), p. 2446-2454, 2016 - PubMed


• M. Kennis, S.J.H. van Rooij, R.S. Kahn, E. Geuze, A. Leemans, "Choosing the polarity of the phase-encoding direction in diffusion MRI: Does it matter for group analysis?", NeuroImage: Clinical, Vol. 11, p. 539-547, 2016 - PubMed


• C.E. Kelly, D.K. Thompson, J. Chen, A. Leemans, C.L. Adamson, T.E. Inder, J.L.Y. Cheong, L.W. Doyle, P.J. Anderson, "Axon density and axon orientation dispersion in children born preterm", Human Brain Mapping, Vol. 37(9), p. 3080-3102, 2016 - PubMed


• W. Huizinga, D.H.J. Poot, J.-M. Guyader, R. Klaassen, B.F. Coolen, M. van Kranenburg, R.J.M. van Geuns, A. Uitterdijk, M. Polfliet, J. Vandemeulebroucke, A. Leemans, W.J. Niessen, S. Klein, "PCA-based groupwise image registration for quantitative MRI", Medical Image Analysis, Vol. 29, p. 65-78, 2016 - PubMed


• W. Haakma, M. Pedersen, M. Froeling, L. Uhrenholt, A. Leemans, L. Warner Thorup Boel, "Diffusion tensor imaging of peripheral nerves in non-fixed post-mortem subjects", Forensic Science International, Vol. 263, p. 139-146, 2016 - PubMed


• D. Perrone, B. Jeurissen, J. Aelterman, T. Roine, J. Sijbers, A. Pizurica, A. Leemans, W. Philips, "D-BRAIN: Anatomically accurate simulated diffusion MRI brain data", PLoS One, Vol. 11(3), p. e0149778, 2016 - PubMed


• E. O'Hanlon, S. Howley, S. Prasad, J. McGrath, A. Leemans, C. McDonald, H. Garavan, K.C. Murphy, "Multimodal MRI reveals structural connectivity differences in 22q11 deletion syndrome related to impaired spatial working memory", Human Brain Mapping, Vol. 37(12), p. 4689-4705, 2016 - PubMed


• J. Debrabant, G. Vingerhoets, H. Van Waelvelde, A. Leemans, T. Taymans, K. Caeyenberghs, "Brain connectomics of visual-motor deficits in children with developmental coordination disorder", Journal of Pediatrics, Vol. 169, p. 21-27, 2016 - PubMed


• C.E. Kelly, J.L.Y. Cheong, L. Gabra Fam, A. Leemans, M.L. Seal, L.W. Doyle, P.J. Anderson, A.J. Spittle, D.K. Thompson, "Moderate and Late Preterm Infants Exhibit Widespread Brain White Matter Microstructure Alterations at Term-Equivalent Age Relative to Term-Born Controls", Brain Imaging and Behavior, Brain Imaging and Behavior, Vol. 10(1), p. 41-49, 2016 - PubMed


• A.L. Murray, D.K. Thompson, L. Pascoe, A. Leemans, T.E. Inder, L.W. Doyle, J.F.I. Anderson, P.J. Anderson, "White matter abnormalities and impaired attention abilities in children born very preterm", NeuroImage, Vol. 124, p. 75-84, 2016 - PubMed


• M. Catani, F. Dell'Acqua, H. Howells, S. Budisavljevic, M. Thiebaut de Schotten, S. Froudist Walsh, L. D'Anna, A. Thompson, S. Sandrone, E.T. Bullmore, J. Suckling, S. Bar-on-Cohen, M.V. Lombardo, S.J. Wheelwright, B. Chakrabarti, M.-C. Lai, A.N.V. Ruigrok, A. Leemans, C. Ecker, MRC AIMS Consortium, M.C. Craig, D.G.M. Murphy, "Frontal networks in adults with autism spectrum disorder", Brain, Vol. 139, p. 616-630, 2016 - PubMed


• S.B. Vos, M. Aksoy, Z. Han, S.J. Holdsworth, J. Maclaren, M.A. Viergever, A. Leemans, R. Bammer, "Trade-off between angular and spatial resiolution in in vivo fiber tractography", NeuroImage, Vol. 129, p. 117-132, 2016 - PubMed


• D.K. Thompson, K.J. Lee, L. van Bijnen, A. Leemans, L. Pascoe, S.E. Scratch, J. Cheong, G.F. Egan, T.E. Inder, L.W. Doyle, P.J. Anderson, "Accelerated corpus callosum development in prematurity predicts improved outcome", Human Brain Mapping, Vol. 124, p. 75-84, 2016 - PubMed


• R.A. Poldrack, T.O. Laumann, O. Koyejo, B. Gregory, A. Hover, M.-Y. Chen, K.J. Gorgolewski, J. Luci, S.J. Joo, R.L. Boyd, S. Hunicke-Smith, Z.B. Simpson, T. Caven, V. Sochat, J.M. Shine, E. Gordon, A.Z. Snyder, B. Adeyemo, S.E. Petersen, D.C. Glahn, D. Reese McKay, J.E. Curran, H.H. G?ring, M.A. Carless, J. Blangero, R. Dougherty, A. Leemans, D.A. Handwerker, L. Frick, E.M. Marcotte, J.A. Mumford, "Long-term neural, behavioral, and physiological phenotyping of a single human: The MyConnectome Project", Nature Communications, Vol. 6(8885), p. 1-15, 2015 - PubMed


• D. Perrone, J. Aelterman, A. Pi?urica, B. Jeurissen, W. Philips, A. Leemans, "The effect of Gibbs ringing artifacts on measures derived from diffusion MRI", NeuroImage, Vol. 120, p. 441-455, 2015 - PubMed


• J. Shin, C. Bourdon, M. Bernard, M.D. Wilson, E. Reischl, M. Waldenberger, B. Ruggeri, G. Schumann, S. Desrivieres, A. Leemans, IMAGEN Consortium, SYS Consortium, M. Abrahamowicz, G. Leonard, L. Richer, L. Bouchard, D. Gaudet, T. Paus, Z. Pausova, "Layered genetic control of DNA methylation and gene expression: A locus of multiple sclerosis in healthy individuals", Human Molecular Genetics, Vol. 24(20), p. 5733-5745, 2015 - PubMed


• Y.D. Reijmer, P. Fotiadis, S. Martinez-Ramirez, D.H. Salat, A. Schultz, A. Shoamanesh, A.M. Ayres, A. Vashkevich, D. Rosas, K. Schwab, A. Leemans, G.J. Biessels, J. Rosand, K.A. Johnson, A. Viswanathan, M.E. Gurol, S.M. Greenberg, "Structural network alterations and neurologic dysfunction in cerebral amyloid angiopathy", Brain, Vol. 138(1), p. 179-188, 2015 - PubMed


• A. Versace, H. Acuff, M.A. Bertocci, G. Bebko, J.R.C. Almeida, S.B. Perlman, A. Leemans, C. Schirda, H. Aslam, A. Dwojak, L. Bonar, M. Travis, M.K. Gill, C. Demeter, V.A. Diwadkar, J.L. Sunshine, S.K. Holland, R.A. Kowatch, B. Birmaher, D. Axelson, S.M. Horwitz, T.W. Frazier, L.E. Arnold, M.A. Fristad, E.A. Youngstrom, R.L. Findling, M.L. Phillips, "White Matter Structure in Youth with Behavioral and Emotional Dysregulation Disorders: a Probabilistic Tractographic Study", JAMA Psychiatry, Vol. 72(4), p. 367-376, 2015 - PubMed


• E. O'Hanlon, A. Leemans, I. Kelleher, M.C. Clarke, S. Roddy, H. Coughlan, M. Harley, F. Amico, M. Hoscheit, L. Tiedt, J. Tabish, A. McGettigan, T. Frodl, M. Cannon, "White matter differences among adolescents reporting psychotic experiences. A population-based diffusion MRI study", JAMA Psychiatry, Vol. 72(2), p. 668-677, 2015 - PubMed


• U. Roine, J. Salmi, T. Roine, T. Nieminen-von Wendt, S. Lepp?m?ki, P. Rintahaka, P. Tani, A. Leemans, M. Sams, "Constrained spherical deconvolution-based tractography and tract-based spatial statistics show abnormal microstructural organization in Asperger syndrome", Molecular Autism, Vol. 6, p. 1-11, 2015 - PubMed


• Y.D. Reijmer, A.P. Schultz, A. Leemans, M.J. O'Sullivan, M.E. Gurol, R. Sperling, S.M. Greenberg, A. Viswanathan, T. Hedden, "Decoupling of structural and functional brain connectivity in older adults with white matter hyperintensities", NeuroImage, Vol. 117, p. 222-229, 2015 - PubMed


• O.F.F. Odish, A. Leemans, R.H.A.M. Reijntjes, S.J.A. van den Bogaard, E.M. Dumas, R. Wolterbeek, C.M.W. Tax, H.J. Kuijf, K.L. Vincken, J. van der Grond, R.A.C. Roos, "Microstructural brain abnormalities in Huntington's disease: a two year follow-up", Human Brain Mapping, Vol. 36(6), p. 2061-2074, 2015 - PubMed


• S.B. Vos, W. Haakma, H. Versnel, M. Froeling, L. Speleman, P. Dik, M.A. Viergever, A. Leemans, W. Grolman, "Diffusion tensor imaging of the auditory nerve in patients with long-term single-sided deafness", Hearing Research, Vol. 323, p. 1-8, 2015 - PubMed


• N. De Geeter, G. Crevecoeur, A. Leemans, L. Dupre, "Effective electric fields along realistic DTI-based neural trajectories for modelling the stimulation mechanisms of TMS", Physics in Medicine and Biology, Vol. 60, p. 453-471, 2015 - PubMed


• L. Serbruyns, J. Gooijers, K. Caeyenberghs, R.L. Meesen, K. Cuypers, H.M. Sisti, A. Leemans, S.P. Swinnen, "Bimanual motor deficits in older adults predicted by diffusion tensor imaging metrics of corpus callosum subregions", Brain Structure and Function, Vol. 220, p. 273-290, 2015 - PubMed


• C.M.W. Tax, W.M. Otte, M.A. Viergever, R.M. Dijkhuizen, A. Leemans, "REKINDLE: Robust Extraction of Kurtosis INDices with Linear Estimation", Magnetic Resonance in Medicine, Vol. 73(2), p. 794-808, 2015 - PubMed


• C.M.W. Tax, B. Jeurissen, S.B. Vos, M.A. Viergever, and A. Leemans, "Recursive calibration of the fiber response function for spherical deconvolution of diffusion MRI data", NeuroImage, Vol. 86, p. 67-80, 2014 - PubMed


• K. Caeyenberghs, A. Leemans, "Hemispheric lateralization of topological organization in structural brain networks", Human Brain Mapping, Vol. 35, p. 4944-4957, 2014 - PubMed


• M. Bach, F.B. Laun, A. Leemans, C.M.W. Tax, G.J. Biessels, B. Stieltjes, K.H. Maier-Hein, "Methodological considerations on Tract-Based Spatial Statistics (TBSS)", NeuroImage, Vol. 100, p. 358-369, 2014 - PubMed


• J. McGrath, K. Johnson, E. O'Hanlon, H. Garavan, L. Gallagher, and A. Leemans, "White matter and visuospatial processing in autism: A constrained spherical deconvolution tractography study", Autism Research, Vol. 6(5), p. 307-319, 2013 - PubMed


• S. Deprez, T. Billiet, S. Sunaert, and A. Leemans, "Diffusion tensor MRI of chemotherapy-induced cognitive impairment in non-CNS cancer patients: A review", Brain Imaging and Behavior, Vol. 7(4), p. 409-435, 2013 - PubMed


• B. Jeurissen, A. Leemans, J.D. Tournier, D.K. Jones, J. Sijbers, "Investigating the prevalence of complex fiber configurations in white matter tissue with diffusion MRI", Human Brain Mapping, Vol. 34, p. 2747-2766, 2013 - PubMed


• Y.D. Reijmer, A. Leemans, K. Caeyenberghs, S.M. Heringa, D.L. Koek, and G.J. Biessels, "Disruption of cerebral networks and cognitive impairment in Alzheimer's disease", Neurology, Vol. 15, p. 1370-1377, 2013 - PubMed


• H.C. Wang, J.L. Hsu, and A. Leemans, "Diffusion Tensor Imaging of Vascular Parkinsonism: Structural Changes in Cerebral White Matter and the Association with Clinical Severity", Archives of Neurology, Vol. 69(10), p. 1340-1348, 2012 - PubMed


• P.K.N. van der Jagt, P. Dik, M. Froeling, T.C. Kwee, R.A.J. Nievelstein, B. ten Haken, and A. Leemans, "Architectural configuration and microstructural properties of the sacral plexus: A diffusion tensor MRI and tractography study", NeuroImage, Vol. 62(3), p. 1792-1799, 2012 - PubMed


• S.B. Vos, B. Jeurissen, D.K. Jones, M.A. Viergever, and A. Leemans, "The influence of complex white matter architecture on the mean diffusivity in diffusion tensor MRI of the human brain", NeuroImage, Vol. 59(3), p. 2208-2216, 2012 - PubMed


• J.L. Hsu, Y.L. Chen, J.G. Leu, F.S. Jaw, C.H. Lee, Y.F. Tsai, C.Y. Hsu, C.H. Bai, and A. Leemans, "Microstructural white matter abnormalities in type 2 diabetes mellitus: A diffusion tensor imaging study", NeuroImage, Vol. 59(2), p. 1098-1105, 2012 - PubMed


• S. Deprez, F. Amant, A. Smeets, R. Peeters, A. Leemans, W. Van Hecke, M-R. Christiaens, J. Vandenberghe, M. Vandenbulcke, S. Sunaert, "Longitudinal assessment of chemotherapy-induced structural changes in cerebral white matter and its correlation with impaired cognitive functioning", Journal of Clinical Oncology, Vol. 30(3), p. 274-281, 2012 - PubMed


• M. Langen, A. Leemans, P. Johnston, C. Ecker, E. Daly, C.M. Murphy, F. dell'Acqua, S. Durston, the AIMS Consortium, and D.G.M. Murphy, "Fronto-striatal circuitry and inhibitory control in autism: Findings from diffusion tensor imaging tractography", Cortex, Vol. 48(2), p. 183-193, 2012 - PubMed


• N.E. van der Aa, A. Leemans, F.J. Northington, H.L.M. van Straaten, I.C. van Haastert, F. Groenendaal, M.N.J.L. Benders, and L.S. de Vries, "Does DTI-based tractography at three months contribute to the prediction of motor outcome following perinatal arterial ischemic stroke?", Stroke, Vol. 42(12), p. 3410-3414, 2011 - PubMed


• J.D. Tournier, S. Mori, and A. Leemans, "Diffusion tensor imaging and beyond", Magnetic Resonance in Medicine, Vol. 65(6), p. 1532-1556, 2011 - PubMed


• S.B. Vos, D.K. Jones, M.A. Viergever, and A. Leemans, "Partial volume effect as a hidden covariate in DTI analyses", NeuroImage, Vol. 55(4), p. 1566-1576, 2011 - PubMed


• B. Jeurissen, A. Leemans, D.K. Jones, J.-D. Tournier, and J. Sijbers, "Probabilistic fiber tracking using the residual bootstrap with constrained spherical deconvolution", Human Brain Mapping, Vol. 32(3), p. 461-479, 2011 - PubMed


• K. Caeyenberghs, A. Leemans, M. Geurts, T. Taymans, C. Vander Linden, B.C.M. Smits-Engelsman, S. Sunaert, and S.P. Swinnen, "Brain-behavior relationships in young traumatic brain injury patients: DTI metrics are highly correlated with postural control", Human Brain Mapping, Vol. 31(7), p. 992-1002, 2010 - PubMed


• J.-L. Hsu, W. Van Hecke, C.-H. Bai, C.-H. Lee, Y.-F. Tsai, H.-C, Chiu, F.-S. Jaw, C.-Y. Hsu, J.-G. Leu, W.-H. Chen, and A. Leemans, "Microstructural white matter changes in normal aging: A diffusion tensor imaging study with higher-order polynomial regression models", NeuroImage, Vol. 49(1), p. 32-43, 2010 - PubMed


• A. Leemans and D.K. Jones, "The B-matrix must be rotated when correcting for subject motion in DTI data", Magnetic Resonance in Medicine, Vol. 62(1), p. 1336-1349, 2009 - PubMed


• W. Van Hecke, J. Sijbers, E. D'Agostino, F. Maes, S. De Backer, E. Vandervliet, P.M. Parizel, A. Leemans, "On the construction of an inter-subject diffusion tensor magnetic resonance atlas of the healthy human brain", NeuroImage, Vol. 43(1), p. 69-80, 2008 - PubMed


• C. Lebel, L. Walker, A. Leemans, L. Phillips, and C. Beaulieu, "Microstructural Maturation of the Human Brain from Childhood to Adulthood", NeuroImage, Vol. 40(3), p. 1044-1055, 2008 - PubMed


• J.-L. Hsu, A. Leemans, C.-H. Bai, C.-H. Lee, Y.-F. Tsai, H.-C. Chiu, W.-H. Chen, "Gender differences and age-related white matter changes of the human brain: a diffusion tensor imaging study", NeuroImage, Vol. 39(2), p. 566-577, 2008 - PubMed


• W. Van Hecke, A. Leemans, E. D'Agostino, S. De Backer, E. Vandervliet, P.M. Parizel, and J. Sijbers, "Nonrigid coregistration of diffusion tensor images using a viscous fluid model and mutual information", IEEE Transactions in Medical Imaging, Vol. 26(11), p. 1598-1612, 2007 - PubMed

More publications (with document access) can be found on the publications section of the Image Sciences Institute.